Phytochemicals as Potential Anti-Alzheimer’s Agents- An In-Silico Evidence

Alzheimer’s Disease is a prominent neurodegenerative disorder affecting the age group 60 and above. Cholinergic hypothesis, amyloid β cascade, oxidative stress some of known etiologies marked importance to name few. We have undertaken computational analysis where fifteen phytochemicals were selected. These natural molecules studied analysed against acetylcholinesterase, butyrlcholinesterase, BACE monomer protofibril. The binding affinities Genistein, Huperzine A, kaempferol, Methyl quercetin, Paclitaxel Withinolide A AChE BuChE enzymes found be -7.7 -8.6 Kcal/mol, respectively. Various like Piceatannol, Ginkgolide B, quercetin bind BACE-1 enzyme with -6.7 -7.9 Kcal/mol. All experienced efficient towards Aβ was all PDB’s efficiently affinity -8.4, -8.9, -7.7, -6.6 -6.8 Kcal/mol enzyme, protofibril, respectively as result it can carried forward for further preclinical clinical studies.